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              副研究員

              遲亞云 副研究員
              副研究員,博士
              E-mail: yychi@126.com
               

                2005年畢業于復旦大學上海醫學院獲得醫學學士學位,2010年畢業于復旦大學上海醫學院基礎醫學院獲生物化學與分子生物學博士學位,畢業后任職于復旦大學附屬腫瘤醫院腫瘤研究所,乳腺癌研究所。期間于2014-2015年前往美國田納西大學癌癥研究中心訪問交流。主持多項國家自然科學基金青年項目和面上項目,參加國家重點基礎研究發展計劃、上海市科委基礎研究項目等。研究成果發表于Oncogene, Theranostics,Journal of Biological Chemistry等國際核心雜志。


              研究領域:

                乳腺腫瘤耐藥及侵襲轉移的分子機制和轉化性研究
                1.HER2陽性乳腺癌治療敏感性的多組學研究;
                2.乳腺癌轉移侵襲相關分子標志物的篩選及機制研究;
                3.乳腺癌耐藥及預后相關的分子模型建立及研究。


              代表性論著:

                1.   Yayun Chi#, Jingyan Xue#, Sheng Huang#, Bingqiu Xiu#, Yonghui Su, Wei Wang, Rong Guo, Lei Wang, Lun Li, Zhiming Shao, Wei Jin, Zhaohui Wu*, Jiong Wu*. CapG promotes resistance to paclitaxel in breast cancer through transactivation of PIK3R1/P50. Theranostics.  doi:10.7150/thno.36338.

                2.   Sheng Huang#, Yayun Chi#, Yi Qin#, Ziliang Wang, Bingqiu Xiu, Yonghui Su, Rong Guo, Liang Guo, Hefen Sun, Chujia Zeng, Shuling Zhou, Xin Hu, Sheng Liu, Zhimin Shao, Zhaohui Wu, Wei Jin, Jiong Wu*. CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription. Theranostics, 2018; 8(9): 2549-2564.

                3.   Lei Liu#, Yayun Chi#, Jiajian Chen, Jingyan Xue, Linlin Deng, Naisi Huang, Jianghua Shao & Jiong Wu*. Long non-coding RNA00544 serves as a potential novel predictive and prognostic marker for HR+ HER2?subtype breast cance. Sci Rep, 2017 Sep 28; 7(1):12382.

                4.    Xue J#, Chi Y#, Chen Y, Huang S, Ye X, Niu J, Wang W, Pfeffer LM, Shao ZM, Wu ZH, Wu J: MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. Oncogene, 2016 Jan 28; 35(4):448-58.

                5.    Chi Y#, Huang S#, Liu M, Guo L, Shen X, Wu J. Cyclin D3 predicts disease-free survival in breast cancer. Cancer Cell Int, 2015 Sep 26; 15:89.

                6.    Chi Y#, Huang S#, Peng H, Liu M, Zhao J, Shao Z, Wu J. Critical role of CDK11(p58) in human breast cancer growth and angiogenesis. Bmc Cancer, 2015 Oct 15; 15:701.

                7.    Huang S#, Kou B#, Chi Y#, Xi Y, Cao Y, Cui W, Hu X, Shao Z, Guo H, Fu Y et al. In-line phase-contrast and grating-based phase-contrast synchrotron imaging study of brain micrometastasis of breast cancer. Sci Rep2015 Mar 30; 5:9418.

                8.   Chi Y#, Huang S#, Liu M, Huang N, Zhou S, Zhou B, Wu J. Role of BC040587 as a predictor of poor outcome in breast cancer. Cancer Cell Int, 2014 Nov 26; 14(1):123.

                9.   Chi Y#, Huang S#, Wang L, Zhou R, Wang L, Xiao X, Li D, Cai Y, Zhou X, Wu J. CDK11p58 inhibits ERalpha-positive breast cancer invasion by targeting integrin beta3 via the repression of ERalpha signaling. BMC Cancer, 2014 Aug 8; 14:577.

                10.  Chi Y, Wang L, Xiao X, Wei P, Wang Y, Zhou X. Abnormal expression of CDK11p58 in prostate cancer. Cancer Cell Int, 2014 Jan 8; 14(1):2.

                11.  Chi Y#, Zhang C#, Zong H, Hong Y, Kong X, Liu H, Zou W, Wang Y, Yun X, Gu J: Thr-370 is responsible for CDK11(p58) autophosphorylation, dimerization, and kinase activity. J Biol Chem, 2011 Jan 21; 286(3):1748-57.


               
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