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              專職PI
              李大強 研究員
              研究員,博士生導師
              E-mail: daqiangli1974@fudan.edu.cn
               

                1998年7月及2003年7月在重慶醫科大學分別獲得醫學學士學位及醫學博士學位。2003年8月至2009年10月先后在復旦大學附屬腫瘤醫院、美國凱斯西儲大學 (Case Western Reserve University)、德州大學安德森腫瘤中心 (University of Texas M.D. Anderson Cancer Center) 及喬治華盛頓大學 (George Washington University) 從事博士后研究工作。2009年11月起任喬治華盛頓大學生物化學及分子生物學系Faculty 及Assistant Research Professor,并于2013年7月升職為Associate Research Professor。2013年9月回國任復旦大學生物醫學研究院及腫瘤研究所雙聘PI,研究員,入選2013年上海高校特聘教授 (東方學者)。

                一直致力于腫瘤侵襲轉移及治療耐藥的分子機制研究,為尋找干預腫瘤轉移和治療耐藥的候選藥物靶標提供線索,在Cancer Cell、Mol Cell、Cell Rep、Hepatology、J Cell Biol、Nat Commun、PNAS、Autophagy、Nucleic Acids Res、Cancer Res以及Cell Death Differ等國際期刊上發表SCI論文50余篇。目前擔任Cancer Research等雜志編委以及Cancer Research等多個雜志的審稿人。


              研究領域:

                腫瘤侵襲轉移及治療耐藥的分子機制


              研究團隊:



              代表性論著:

              1. Zhang L, Li DQ*. MORC2 regulates DNA damage response through a PARP1-dependent pathway. Nucleic Acids Research, 2019; 47(17): 9132–9143.
              2. Yang F, Xie HY, Yang LF, Zhang L, Zhang FL, Liu HY, Li DQ*, Shao ZM*. Stabilization of MORC2 by estrogen and antiestrogens through GPER1-KAPCA-CMA pathway contributes to estrogen-induced proliferation and endocrine resistance of breast cancer cells. Autophagy, 2019 (Published Online: 06 Sep 2019).
              3. Yang YL, Zhang Y, Li DD, Zhang FL, Liu HY, Liao XH, Xie HY, Lu Q, Zhang L, Hong Q, Dong WJ, Li DQ*, Shao ZM*. RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2. Cell Death Differentiation, 2019 [PMID: 31406303].
              4. Zhang FL, Cao JL, Xie HY, Sun R, Yang LF, Shao ZM*, Li DQ*. Cancer-Associated MORC2- Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer. Cancer Research, 2018; 78(20): 5780- 5792.
              5. Sun R, Xie HY, Qian JX, Huang YN, Yang F, Zhang FL, Shao ZM*, Li DQ*. FBXO22 Possesses Both Protumorigenic and Antimetastatic Roles in Breast Cancer Progression. Cancer Research, 2018; 78(18): 5274-5286.
              6. Li DQ#, Pakala SB#, Reddy SD, Peng S, Balasenthil S, Deng CX, Lee CC, Rea MA, Kumar R. Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun, 2013; 4:2545. 
              7. Li DQ*, Nair SS, Ohshiro K, Kumar A, Nair VS, Pakala SB, Reddy SD, Gajula RP, Eswaran J, Aravind L, Kumar R*. MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. Cell Rep, 2012; 2:1657–1669.
              8. Li DQ, Pakala SB, Reddy SD, Ohshiro K, Zhang JX, Wang L, Zhang Y, de Alborán IM, Pillai MR, Eswaran J, Kumar R. Bidirectional autoregulatory mechanism of metastasis  associated protein 1-alternative reading frame pathway in oncogenesis. Proc Natl Acad Sci U S A, 2011; 108: 8791-8796.
              9. Li DQ, Ohshiro K, Reddy SD, Pakala SB, Lee MH, Zhang Y, Rayala SK, Kumar R. E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A, 2009; 106: 17493-17498.
              10. Li DQ, Pakala SB, Nair SS, Eswaran J, Kumar R. Metastasis-associated protein 1 /nucleosome remodeling and histone deacetylase complex in cancer. Cancer Res, 2012; 72: 387-394.
              11. Zhang JX#, Li DQ#,*, He AR, Motwani M, Vasiliou V, Eswaran J, Mishra L, Kumar R. Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP-ribose) polymerases. Hepatology, 2012; 55: 1840-1851. 
              12. Molli PR#, Li DQ#, Bagheri-Yarmand R, Pakala SB, Katayama H, Sen S, Iyer J, Chernoff J, Tsai MY, Nair SS, Kumar R. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol, 2010; 190:101-114. (評論見Nat Rev Mol Cell Biol, 2010; 11: 542)
              13. Miao H, Li DQ, Mukherjee A, Guo H, Petty A, Cutter J, Basilion JP, Sedor J, Wu J, Danielpour D, Sloan AE, Cohen ML, Wang B. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell, 2009; 16: 9-20. (評論見Nature, 2009; 461:149)
              14. Nair SS, Li DQ, Kumar R. A core chromatin remodeling factor instructs global chromatin signaling through multivalent reading of nucleosome codes. Mol Cell, 2013; 49(4):704-18.
              15. Li DQ, Ohshiro K, Khan MN, Kumar R. Requirement of MTA1 in ATR-mediated DNA damage checkpoint function. J Biol Chem, 2010; 285(26):19802-12.
              16. Li DQ#, Pakala SB#, Reddy SD, Ohshiro K, Peng SH, Lian Y, Fu SW, Kumar R. Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway. J Biol Chem, 2010; 285(13): 10044-52.
              17. Li DQ, Divijendra Natha Reddy S, Pakala SB, Wu X, Zhang Y, Rayala SK, Kumar R. MTA1 coregulator regulates p53 stability and function. J Biol Chem, 2009; 284(50): 34545-52.
              18. Li DQ, Hou YF, Wu J, Chen Y, Lu JS, Di GH, Ou ZL, Shen ZZ, Ding J, Shao ZM. Gene expression profile analysis of an isogenic tumour metastasis model reveals a functional role for oncogene AF1Q in breast cancer metastasis. Eur J Cancer, 2006; 42(18):3274-86.
              19. Li DQ, Wang L, Fei F, Hou YF, Luo JM; Wei-Chen, Zeng R, Wu J, Lu JS, Di GH, Ou ZL, Xia QC, Shen ZZ, Shao ZM. Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry. Proteomics, 2006; 6(11): 3352-68.
              20. Li DQ*, Kumar R*. Unravelling the Complexity and Functions of MTA Coregulators in Human Cancer. Adv Cancer Res, 2015;127: 1-47.
              21. Li DQ*, Yang Y, Kumar R*. MTA family of proteins in DNA damage response: mechanistic insights and potential applications. Cancer Metastasis Rev, 2014; 33(4): 993-1000.
              22. Li DQ, Nair SS, Kumar R. The MORC family: new epigenetic regulators of transcription and DNA damage response. Epigenetics, 2013; 8(7): 685-93.
              23. Li DQ, Kumar R. Mi-2/NuRD complex making inroads into DNA-damage response pathway. Cell Cycle, 2010; 9(11): 2071-9.
              24. Kumar R*, Li DQ*. PAKs in Human Cancer Progression: From Inception to Cancer Therapeutic to Future Oncobiology. Adv Cancer Res, 2016;130:137-209.
              25. Zhang Y, Yang YL, Zhang FL, Liao XH, Shao ZM*, Li DQ*. Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4. Cancer Med, 2018; 7(4): 1317-1325.
              26. Liao XH, Zhang Y, Dong WJ, Shao ZM*, Li DQ*. Chromatin remodeling protein MORC2 promotes breast cancer invasion and metastasis through a PRD domain-mediated interaction with CTNND1. Oncotarget, 2017; 8(58): 97941-97954.
              27. Zhang Y, Liao XH, Xie HY, Shao ZM*, Li DQ*. RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells. Oncotarget, 2017; 8(55): 94505-94518.
              28. Xie HY, Shao ZM*, Li DQ*. Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis. Chin J Cancer, 2017; 36(1):36.
               
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