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              臨床PI
              蔡三軍 教授
              教授,博士生導師
              E-mail: caisanjuncsj@163.com
               

                復旦大學附屬腫瘤醫院大腸癌多學科協作組首席專家、復旦大學大腸癌診治中心主任、上海市抗癌協會大腸癌專業委員會主任委員、中國抗癌協會大腸癌專業委員會前主任委員、美國臨床腫瘤指南(NCCN)中國版專家委員會委員、NCCN大腸癌臨床實踐指南(中國版)外科執筆人、主要從事結直腸癌基礎和臨床研究,尤其擅長于大腸癌的手術治療,是中國著名的大腸癌專家。 

                    主編《結直腸肛門腫瘤》(北京大學出版社,2005)及《循證結直腸肛管腫瘤學》(上海科學技術出版社2015)。主持國家自然科學基金課題、國家863及973、復旦211等重大科研課題,累計經費4200余萬。

                    近5年發表醫學論文90余篇,其中SCI 70余篇。2012獲得上海市科學技術及教育部科技進步二等獎,2018獲上海預防醫學會科學技術二等獎,2019獲第三屆國之名醫盛典-卓越建樹獎和科教資訊一等獎。


              研究領域:

              1、大腸癌、胃癌、軟組織腹膜后腫瘤、惡性黑色素瘤等腹部腫瘤的手術治療;
              2、局部晚期大腸癌及復發轉移性大腸癌的綜合治療;
              3、大腸癌的早期篩查、分子生物標志物及復發轉移機制研究;
              4、大腸癌類器官平臺建設與轉化治療。



              研究團隊:

               自2005年來擔任復旦大學大腸癌中心主委、腫瘤醫院大腸癌多學科協作組首席科學家,對大腸癌診治方面的各種治療方式、綜合治療、個體化治療有較深的理解,形成了國內最好的大腸癌MDT隊伍,團隊包括大腸外科、放療科、腫瘤內科、病理科、放射診斷、內鏡科、肝外科、介入科及中醫科,積極推動了國內大腸癌的規范性多學科綜合治療的發展。




              代表性論著:

              1. Li Q#, Wei P#, Wu J, Zhang M, Li G, Li Y, Xu Y, Li X, Xie D, Cai S*, Xie K*, Li D*. The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect. Oncogene, 2019Jan; 38(4):483-496.
              2. Hu X#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Adjuvant Chemotherapy Seemed Not to Have Survival Benefit in Rectal Cancer Patients with ypTis-2N0 After Preoperative Radiotherapy and Surgery from a Population-Based Propensity Score Analysis. Oncologist, 2019 Jun; 24(6):803-811.
              3. Li Y#, Wang R#, Huang D#, Ma X, Mo S, Guo Q, Fu G, Li Y, Xu X, Hu X, Zhou Y, Deng Y, Zhang L, Chen H, Gao J, Zhang Z, Cai S*, Hua G*, Peng J*. A novel human colon signet-ring cell carcinoma organoid line: establishment, characterization and application. Carcinogenesis, 2019 Nov 19.
              4. Zhang S#, Yang Y, Weng W, Guo B, Cai G, Ma Y, Cai S*. Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer. J Exp Clin Cancer Res, 2019 Jan 10; 38(1):14.
              5. Hu X#, Li YQ, Ma XJ, Zhang L, Cai SJ*, Peng JJ*. A Risk Signature With Inflammatory and T Immune Cells Infiltration in Colorectal Cancer Predicting Distant Metastases and Efficiency of Chemotherapy. Front Oncol, 2019 Aug 13; 9:704.
              6. Feng Y#, Li Y, Huang D, Cai S*, Peng J*. HER2 as a potential biomarker guiding adjuvant chemotherapy in stage II colorectal cancer. Eur J Surg Oncol, 2019 Feb; 45(2):167-173.
              7. Hu X#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway. J Exp Clin Cancer Res, 2018 Mar 2; 37(1):41.
              8. Li Q#, Li Y#, Li J, Ma Y, Dai W, Mo S, Xu Y, Li X*, Cai S*. FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1alpha/CEACAM5 functional axis. Int J Biol Sci,  2018 May 12; 14(7):726-735.
              9. Hu X#, Li YQ, Li QG, Ma YL, Peng JJ*, Cai SJ*. Baseline Peripheral Blood Leukocytosis Is Negatively Correlated With T-Cell Infiltration Predicting Worse Outcome in Colorectal Cancers. Front Immunol, 2018 Oct 12; 9:2354.
              10. Hu X#, Li YQ, Li QG, Ma YL, Peng JJ*, Cai SJ*. ITGAE Defines CD8+ Tumor-Infiltrating Lymphocytes Predicting a better Prognostic Survival in Colorectal Cancer. EBioMedicine, 2018 Sep; 35:178-188.
              11. Hu X#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Osteoglycin-induced VEGF Inhibition Enhances T Lymphocytes Infiltrating in Colorectal Cancer. EBioMedicine, 2018 Aug; 34:35-45.
              12. Li Q#, Dai W#, Jia H#, Li Y, Xu Y, Li X*, Cai G*, Cai S*. Prognostic Impact of Hypochloremia in Patients With Stage I to III Colorectal Cancer After Radical Resection. Dis Colon Rectum, 2018 Nov; 61(11):1273-1280.
              13. Li Y#, Feng Y#, Dai W, Li Q, Cai S*, Peng J*. Prognostic Effect of Tumor Sidedness in Colorectal Cancer: A SEER-Based Analysis. Clin Colorectal Cancer, 2019 Mar; 18(1):e104-e116.
              14. Yang Y#, Weng W#, Peng J#, Hong L#, Yang L, Toiyama Y, Gao R, Liu M, Yin M, Pan C, Li H, Guo B, Zhu Q, Wei Q, Moyer MP, Wang P, Cai S*, Goel A*, Qin H*, Ma Y*. Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-kappaB, and Up-regulating Expression of MicroRNA-21. Gastroenterology, 2017 Mar; 152(4):851-866.
              15. Shi D#, Liang L#, Zheng H, Cai G, Li X, Xu Y*, Cai S*. Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in colorectal cancer. Biomed Pharmacother, 2017 Jan; 85:355-361.
              16. Li Y#, Liang L#, Dai W, Cai G, Xu Y, Li X, Li Q*, Cai S*. Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer. Mol Cancer, 2016 Aug 24; 15(1):55.
              17. Wang S#, Zhang Q#, Yang P, Yu X, Huang LY, Shen S*, Cai S*. Manganese Oxide-Coated Carbon Nanotubes As Dual-Modality Lymph Mapping Agents for Photothermal Therapy of Tumor Metastasis. ACS Applied Materials & Interfaces, 2016 Feb 17; 8(6):3736-43.
              18. Li Y#, Jia H#, Yu W, Xu Y, Li X, Li Q*, Cai S*. Nomograms for predicting prognostic value of inflammatory biomarkers in colorectal cancer patients after radical resection. Int J Cancer, 2016 Jul 1; 139(1):220-31.
              19. Li Q#, Wei P#, Huang B#, Xu Y, Li X, Li Y, Cai S*, Li D*. MAEL expression links epithelial-mesenchymal transition and stem cell properties in colorectal cancer. Int J Cancer, 2016; 139:2502-11.
              20. Li Q#, Qin Y#, Wei P, Lian P, Li Y, Xu Y, Li X, Li D*, Cai S*. Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma. Mol Cancer Res, 2016 Sep; 14(9):830-40.
              21. Li X#, Liang L#, Huang L, Ma X, Li D, Cai S*. High expression of protein phosphatase 4 is associated with the aggressive malignant behavior of colorectal carcinoma. Mol Cancer, 2015 Apr 28; 14:95.
              22. Li Q#, Meng X#, Liang L, Xu Y, Cai G*, Cai S*. High preoperative serum globulin in rectal cancer treated with neoadjunctive chemoradiation therapy is a risk factor for poor outcome. Am J Cancer Res, 2015 Aug 15; 5(9):2856-64.
              23. Li Q#, Wu J#, Wei P, Xu Y, Zhuo C, Wang Y, Li D, Cai S*. Overexpression of forkhead Box C2 promotes tumor metastasis and indicates poor prognosis in colon cancer via regulating epithelial-mesenchymal transition. Am J Cancer Res, 2015 May 15; 5(6):2022-34.
              24. Zhuo C#, Li Z, Xu Y, Wang Y, Li Q, Peng J, Zheng H, Wu P, Li B*, Cai S*. Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival. Molecular Cancer, 2014 Jun 18; 13:153.
              25. Xu Y#, Xu Q#, Yang L, Ye X, Liu F, Wu F, Ni S, Tan C, Cai G, Meng X, Cai S*, Du X*. Identification and validation of a blood-based 18-gene expression signature in colorectal cancer. Clin Cancer Res, 2013 Jun 1; 19(11):3039-49.
              26. Peng J#, Chen W, Venook AP, Sheng W, Xu Y, Guan Z, Cai G, Cai S*. Long-term outcome of early-stage rectal cancer undergoing standard resection and local excision. Clin Colorectal Cancer , 2011 Mar 1; 10(1):37-41.
               
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